An estimated 5.4 million people in the UK have knee osteoarthritis. Arthrosamid injections offer an innovative, long-lasting treatment for knee pain caused by the condition. From a single injection, Arthrosamid can provide sustained symptom relief and improved mobility.
At LivingCare, our experienced consultants offer Arthrosamid injections across our locations in Sheffield and Leeds. With rapid access to appointments and personalised assessments, patients can expect prompt treatment from experienced consultants.
Arthrosamid is a non-steroid, non-degradable injectable hydrogel developed specifically to treat knee osteoarthritis. It acts by reducing pain and stiffness while improving joint function .
While traditional steroid or hyaluronic acid injections only provide short-lived symptom relief, Arthrosamid remains permanently within the joint. Clinical studies show benefits that last beyond two years, with some reporting improvements for up to five years.
Arthrosamid may be suitable for people with mild to moderate knee osteoarthritis who have not improved with other treatments and want to delay or avoid surgery.
Arthrosamid integrates with the soft tissue lining of the inner knee joint, known as the synovial membrane. As osteoarthritis develops, the synovial membrane can become stiff and inflamed. The hydrogel in the Arthrosamid injection helps reduce stiffness in the lining of an osteoarthritic knee. Supporting the joint lining with hydrogel can reduce pain and discomfort and enhance overall function.
Clinical studies suggest that approximately 80% of patients experience a clinically significant improvement following treatment, although around 20% do not respond. For those who do respond, some studies show that symptom relief lasts for several years.
Arthrosamid is used to treat knee osteoarthritis, also called ‘wear and tear’. As cartilage deteriorates, bones can rub together, increasing joint inflammation. This can cause pain during movement, swelling, stiffness and, in advanced cases, deformity or instability.
Arthrosamid may be particularly suitable for patients with mild to moderate osteoarthritis who wish to avoid or delay surgery.
Arthrosamid offers several potential benefits:
Before Your Appointment
Before your treatment, you will have a consultation with an experienced clinician to assess your suitability. Your specialist will review your medical history, previous treatments and any recent imaging. They will spend time explaining the procedure, expected outcomes and potential risks. If you have previously received steroid or hyaluronic acid injections, your specialist may recommend waiting at least three months before proceeding with Arthrosamid.
During Your Appointment
On the day of your injection, you will be prescribed antibiotics and advised when to take them. The procedure is minimally invasive and typically takes 10 to 15 minutes. The full appointment, including monitoring, lasts approximately 30 minutes.
You’ll lie comfortably while the consultant carefully sterilises the area around the knee. You may have an anaesthetic to reduce discomfort. Using a fine needle, your clinician will inject a 6ml dose of Arthrosamid into the knee joint.
You may feel some pressure and a little discomfort, but the procedure is usually not painful and is well-tolerated.
After Your Appointment
After your injection, you will stay in the clinic for a short period of monitoring. You can walk immediately after the procedure, although we recommend taking it easy for the rest of the day.
You should not drive until the local anaesthetic has worn off, which may take several hours. Be sure to arrange transport home from your appointment. Driving can usually resume the following day.
You may notice mild swelling or discomfort for a few days following the injection.
Arthrosamid has demonstrated a strong safety profile in clinical studies. However, as with any injection, there are potential risks, including:
Your specialist will discuss risks in detail and explain how they apply to your individual circumstances.
During the first 24 to 48 hours after treatment, avoid strenuous or high-impact activities and consider using ice packs if you have any swelling. Keep the injection site clean and dry.
Over the first week, gradually return to normal activities as comfort allows. Avoid high-impact exercise in the early days following the injection.
Physiotherapy and maintaining joint-friendly habits can help preserve function and improve symptoms.
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Pain in osteoarthritis is primarily due to inflammation within the joint and changes to the bone and cartilage. As cartilage degrades, cushioning reduces and inflammation increases. This leads to stiffness, swelling and pain, particularly during movement.
Yes, we can treat both knees. Your consultant will tell you the appropriate timing between treatments.
Most patients begin to notice Arthrosamid remains permanently in the joint. Clinical studies show benefits that last beyond two years, with some reporting improvements for up to five years.improvement within 2-6 weeks after the injection, with benefits continuing to develop over several months.
A local anaesthetic will minimise your discomfort. You may feel some pressure during the injection.
Most patients return to work the following day. On the day of treatment, you are advised to rest.

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Speak to our teamYou can receive this treatment at any one of the locations below.
Your healthcare journey in 4 easy steps
Get in Touch
Call us on Leeds 0113 2494655 or Sheffield 0114 7005811 or use our online booking form to send your enquiry. Let us know your preferred appointment type, either virtual or face to face, and we will work to find a time that suits you.
We Arrange Your Appointment
If you filled out our online booking form, one of our team will contact you within 2 hours with available appointment options. Once your appointment is booked, you will receive an email confirmation with all the details you need.
Attend Your Appointment
Attend your appointment at your chosen time, either virtually or in person, with one of our highly qualified consultants. If your appointment requires a written report, this will be prepared and sent to you within 48 hours.
Aftercare and Follow-Up
If you need any further tests, treatment or follow-up, we will help arrange these for you. If you require a copy of your report or images, please let us know and we will send these promptly.
Your healthcare journey in 4 easy steps
Get in Touch
Call us on Leeds 0113 2494655 or Sheffield 0114 7005811 or use our online booking form to send your enquiry and we will work to find a time that suits you
We Arrange Your Appointment
If you filled out our online booking form, one of our team will contact you within 2 hours with available appointment options. Once your appointment is booked, you will receive an email confirmation with all the details you need.
Attend Your Appointment
Attend your appointment at your chosen time with highly qualified clinicians. If your appointment requires a written report, this will be prepared and sent to you within 48 hours with the option to upgrade to 24 hours.
Aftercare and Follow-Up
If you need any further tests, treatment or follow-up, we will help arrange these for you. If you require a copy of your report or images, please let us know and we will send these promptly.
You can receive this treatment from one of the consultants listed below.
Explore the various options available for this treatment.
With our self-pay service, there are no waiting lists - consultations are offered within 24 hours, with treatment within a week. All costs, including tests or scans, are quoted upfront with no obligation to proceed. Visit our Prices page for full details.
If using medical insurance, contact your provider to confirm coverage for all treatment stages before your first appointment. You’ll need a referral letter from your GP for a private procedure at The LivingCare Group. Once you have it, either you or your GP can book your first appointment with us.